Prostate Cancer Screening & Treatment

Uro-Oncology - Prostate Cancer

What is Prostate Cancer?

Prostate cancer is the top most commonly diagnosed cancer for men in Singapore and the fifth leading cause of death worldwide. The risk of prostate cancer increases with age, especially among men in their 50s. Thankfully, prostate cancer is treatable, and with early detection, you can make a full recovery.

The prostate gland is a walnut-sized gland located below the urinary bladder and is responsible for the production of semen. Its development is controlled by the male hormone testosterone. Prostate cancer is the result of the uncontrolled proliferation of abnormal cells, resulting in a malignant tumour.

What are the symptoms of Prostate Cancer?

Prostate cancer does not cause any symptoms if it is in its early stages. At more advanced stages, some symptoms that you may experience include:

  • Frequent urination at night
  • Having trouble urinating
  • Straining while urinating
  • Decreased flow in urination
  • Blood in urine
  • Blood in semen
  • Feeling that your bladder has not been emptied
  • Bone pain and loss of weight and appetite in the late stages

When to visit a doctor

You should visit a prostate specialist in Singapore if you are experiencing any of the symptoms stated above. Additionally, men aged 50 years old and above or with a family history of prostate cancer may require a urological consultation to discuss prostate cancer screening.

How are Prostate Cancers classified?

Prostate cancer can be classified according to its risk of recurrence after treatment and is classified as low, intermediate, high or very high-risk prostate cancer. Risk classification is dependent on the following factors:

  • Prostate Specific Antigen (PSA)
  • Clinical stage of the cancer
  • Gleason Score — a measure of the aggressiveness of the cancer cells. The higher the score, the more aggressive the cancer cells are. Generally, a score of 6 denotes a non-aggressive type of cancer, while scores of 8-10 denote a highly aggressive form of cancer.

The table below summarises the different risk classifications of prostate cancer.

Low Risk

● PSA < 10 ng/ml And
● Gleason score of <7 And
● Non palpable tumour or a palpable nodule involving less than half of 1 lobe of the prostate

Intermediate Risk

● PSA 10-20 ng/ml Or
● Gleason score of 7 Or
● Palpable nodules involving only 1 lobe of prostate

High Risk

● PSA > 20 ng/ml Or
● Gleason score > 7 Or
● Palpable nodules involving both lobes of prostate

Very High Risk

● Tumour that extends beyond the prostate into surrounding structures Or
● The pelvic lymph nodes are involved

What Causes Prostate Cancer?

It is currently not known for certain what causes prostate cancer. However, there are certain conditions that can increase your risk of getting prostate cancer. Risk factors for prostate cancer are:

  • Older age: Men who are older (above 50 years old) have a higher risk of getting prostate cancer.
  • Family history of prostate cancer: Having a male family member who has been diagnosed with prostate cancer or a close female family member who has been diagnosed with breast cancer may increase your risk of getting prostate cancer.
  • A diet high in animal fat but low in fibre: Observational studies found that a “Western diet” high in animal fat and fried food is often associated with the risk of developing prostate cancer. Although the exact reason for this is unclear, it may have to do with alterations in metabolic and cell signalling pathways leading to prostate cancer.
  • Smoking: Cigarettes contain toxic chemicals and can affect circulating hormone levels.
  • Exposure to cadmium: People who are often exposed to cadmium in their line of work (i.e., metals and manufacturing of batteries, electronics and plastics) are at a higher risk of developing prostate cancer.
  • Human Papillomavirus-16 (HPV-16): Studies show that the HPV-16 virus causes gene mutations, increasing the risk of the development of prostate cancer

Contrary to popular belief, sexual activity is not a risk factor for prostate cancer.

How is Prostate Cancer diagnosed in Singapore?

Prostate cancer can be diagnosed by a series of tests, such as:

  • Digital Rectal Examination (DRE): A digital rectal examination is a physical examination carried out by inserting a gloved and lubricated finger up the rectum to examine the prostate. The prostate will be felt to determine if there are any abnormalities in its texture, size, shape or nodules.
  • Prostate Specific Antigen (PSA) test: A blood sample is drawn, and its PSA levels are analysed to see if they are within the normal range.
  • Ultrasound: A small probe is inserted up the rectum, and ultrasound waves are used to visualise the prostate. However, ultrasound is not reliable for detecting prostate cancer unless the cancer is in its advanced stages. During the ultrasound, tissue samples may be taken for further analysis.
  • Magnetic Resonance Imaging (MRI): The prostate specialist in Singapore may use MRI to generate a clearer image of the prostate. Any abnormal areas in the prostate may be identified for biopsy.

Is there a blood test to diagnose Prostate Cancer?

Yes, there is a blood test to help doctors determine the possibility of prostate cancer. The blood test analyses the levels of PSA (a protein produced by the prostate) in your blood. Unusually high PSA levels in your blood may indicate prostate inflammation, infection, enlargement or cancer.

It is important to note that elevated PSA levels do not necessarily mean that you have prostate cancer. Your urologist may carry out further investigations or a biopsy to confirm the diagnosis.

How to prepare for your first consultation?

No preparation is required. However, if you have any conditions such as haemorrhoids, anal fissures or anal tears, please let your prostate specialist in Singapore know, as these conditions may cause discomfort during the examination.

How is Prostate Cancer treated in Singapore?

Treatment of prostate cancer differs depending on the risk classification and stage of the cancer.

Active surveillance

Active surveillance involves closely monitoring the progress of the cancer. This helps avoid unnecessary treatment, which, in turn, avoids possible complications associated with more aggressive forms of prostate cancer treatment, such as erectile dysfunction and urinary incontinence. For low-risk, localised prostate cancer, active surveillance may be recommended. Active surveillance involves regular blood tests, rectal exams and prostate biopsies to monitor the progression of the cancer. Should there be a progression of cancer, treatment will be given promptly.

Treatment for localised Prostate Cancers

Localised prostate cancer refers to cancer that has not spread to other tissues or organs.

  • Radical prostatectomyThis surgical procedure involves the removal of the entire prostate and seminal vesicles. Surrounding lymph nodes may also be removed if indicated. This can be done through open, laparoscopic or robot-assisted surgery.

    With minimally invasive approaches such as laparoscopic or robot-assisted surgery, surgical incisions are smaller, and recovery is quick. This leads to faster recovery, fewer complications and earlier discharge. Generally, patients can return to their normal activities after two to four weeks.

    Possible long-term complications: Erectile dysfunction, stress urinary incontinence, absence of ejaculate fluid during ejaculation. As such, younger men may want to consider assisted reproduction techniques, such as sperm harvesting.
  • Radiation therapy — Radiation therapy involves the use of high-powered energy rays or particles to kill cancer cells. Short-term hormonal treatment may be incorporated as well. This may consist of about 8 to 30 sessions, depending on the type of radiation schedule.

    Radiation therapy may be recommended for older patients with multiple medical problems who should avoid general anaesthesia.

    Possible long-term complications: Possible complications are similar to surgery. Some patients may develop recurrent bleeding in their stools or urine after radiation treatment.

Treatment for metastatic Prostate Cancer

Metastatic prostate cancer refers to cancer that has spread to other tissues or organs. The metastatic prostate cancer treatment options include

  • Androgen deprivation therapy (ADT) — The aim of ADT is to suppress the testosterone levels in the body and slow down the progression of prostate cancer. ADT can be achieved with either regular injections with medication or surgical removal of both testes. ADT  combined with novel hormonal agents is now the standard of care.  

 

  • Chemotherapy

 

  • Symptomatic treatment — Management of symptoms depends on the sites of the cancer spread. This may include palliative treatment care such as analgesia, radiotherapy, or surgery for symptom management.

Is Prostate Cancer curable?

Yes, prostate cancer is curable if detected and treated early. Early diagnosis translates to earlier prostate cancer treatment and better chances of making a full recovery. Studies have shown that there is a 95-99% 5-year survival rate in men who were diagnosed with low and intermediate prostate cancer while it is localised. This percentage drops to 31% when prostate cancer has spread to other parts of the body.

What makes robot-assisted surgery different from conventional surgery?

Contrary to popular belief, robotic surgery is not performed by a robot independently but is performed by an experienced surgeon who guides the robot for the entire procedure through a console. These technological advancements allow for better visualisation, manual dexterity and control than what is possible with conventional techniques — a combination of the surgeon’s skill and critical thinking with the precision of a machine.

Furthermore, robotic surgery allows access to hard-to-reach areas using small incisions. This leads to a lower risk of complications and shorter recovery times.

Frequently Asked Questions

Prostate cancer is known to be one of the most common cancers in men. Although different individuals may experience different symptoms, most do not have any symptoms at all (especially in the early stages). But there can still be a number of warning signs that one must be aware of, such as:

  • Elevated serum PSA (prostate-specific antigen) levels
  • Haematuria (blood in urine)
  • Urinary symptoms (e.g., frequent urination, poor or weak urine flow, sensation of incomplete emptying of the bladder, urinary hesitancy, etc.)
  • Unexplained weight loss and loss of appetite (often noticed in advanced stages of prostate cancer)
  • Bone pain (usually occurs when the cancer has spread to the bones)

 

In addition to these symptoms, some patients may also experience symptoms such as pain and numbness in their legs and other parts of the body, a new onset of erectile dysfunction, and blood in the semen. Therefore, if you experience  any of these warning signs, it is important to consult an experienced prostate specialist in Singapore to assess you thoroughly so that treatment can be started right away.

Prostate cancer in Singapore is one of the most successfully treated cancers, especially in its early stages. If this cancer is diagnosed and managed early, the prognosis tends to be more favourable. Most prostate specialists in Singapore may use a series of investigations to help them confirm the diagnosis. These tests typically include the prostate-specific antigen blood test (PSA), digital rectal examination (DRE), ultrasound scans, and magnetic resonance imaging (MRI).

Active surveillance plays an integral role in prostate cancer treatment in Singapore (low-risk cancers). For more aggressive prostate cancers, the management plan will depend on the grade, stage, and risk classification of the cancer. Treatment usually involves surgery and radiation therapy, which is  beneficial in treating localised cancers. The main treatment for prostate cancer is radical prostatectomy and it involves removing the entire prostate gland, including the seminal vesicles. If needed, the lymph nodes may also have to be removed.

This procedure may also be carried out laparoscopically or by robot-assisted surgery. However, it must be noted that not all surgeons can perform robotic surgery; only a Urologist who has been trained with the necessary skills can carry out this procedure.

Unfortunately, yes. If the cancer is detected late or left untreated, it has the potential to become life-threatening. However, this is not the case for most prostate cancers, as they usually grow slowly and stay confined to the prostate gland. These patients usually have a very good chance of survival if treatment is commenced promptly. However, those with more aggressive types of prostate cancer may find that the cancer spreads quickly, making management challenging especially in the advanced stages. These cancers will require prompt radical treatment in the form of surgery and/or radiotherapy for the optimal outcomes. Therefore, it is vital to consult a urologist with the experience of treating such advanced cancers.

Prostate cancer in Singapore is the second most commonly diagnosed cancer in males and is typically seen in those over the age of 50. It also has a significant mortality rate, especially for untreated cases in their advanced stages, emphasising the need for early detection and treatment. When it comes to the life expectancy of a person with prostate cancer, those with low Gleason grades are expected to have a 5-year survival rate of over 95%. Conversely, patients whose cancer has spread (metastasised) may have lower survival rates.

The Gleason score is a measure of how aggressive the cancer cells are, and they are graded on a scale of 1 to 5. However, each area of the prostate cancer assessment may have different scores, so the pathologist will examine the cancer cells to determine the most common grades and these will be added to achieve the final score. For instance, if an individual’s largest area with cancer is Grade 3 and another large area indicates Grade 4, the Gleason score for this sample would be 3+4=7. The higher the score, the more aggressive the cancer is. A score of 6 would denote a non-aggressive type of cancer, while a score of 8 and above will indicate that the person may have a highly aggressive form of prostate cancer.

As mentioned previously, the survival rates for localised prostate cancers in the early stages are considerably high. According to data obtained from the American Society of Clinical Oncology, the estimated survival rate for 10 to 15 years after treatment ranges between 95% to 98% (for localised cancers). Although the survival rates for those with distant metastasis (spread to other organs) aren’t usually favourable, aggressive treatment may help them survive their condition for more than five years. 

Need more information? Reach out to our team at Assure Urology & Robotic Centre today and book an appointment with one of the finest and most reputed prostate specialists in Singapore.

Summary

Cancer is a frightening word for most, but with early detection and treatment, prostate cancer can be cured, and you will be able to live your life to the fullest. If you suspect that you may have prostate cancer or are at a higher risk of developing prostate cancer, schedule an appointment with a urology doctor in Singapore to undergo regular screenings and discuss your treatment options.

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