Andrology

Andrology

What is Andrology?

Andrology refers to a branch of urology that has to do with disorders of the male reproductive system. Sexual health is important, so it is vital to get treated as early as possible if you feel like you may be experiencing andrological issues. Many of these conditions can be managed via conservative treatments or surgical intervention.

Read on to find out more about common andrology conditions.

Andropause

Andropause (commonly termed ‘male menopause’) is a condition that involves a drop in testosterone levels in males and generally begins at the age of 40. This can cause a lowered sex drive, moodiness, and a variety of health issues, such as osteoporosis and metabolic syndrome.

Role of testosterone in male sexual and reproductive health

Testosterone plays a huge role in male sexual and reproductive health, such as sperm production and sex drive. Testosterone levels are controlled closely via a feedback loop in the brain. When too much testosterone is produced, the brain sends signals to the pituitary gland, which, in turn, sends signals to the testes to reduce the production of testosterone.

Having too much or too little testosterone in one’s body can also result in health issues.

For example, having abnormally high levels of testosterone can result in low sperm counts, prostate enlargement, as well as mood swings. Having low levels of testosterone can result in low sex drive, small testicles, reduced sperm count or infertility.

Signs and symptoms of andropause

Signs and symptoms of andropause include:

  • Mood swings and irritability
  • Loss of muscle mass
  • Fat redistribution around belly and chest areas
  • Lack of energy
  • Difficulty sleeping or tiredness
  • Poor concentration or memory
  • Decreased sexual libido
  • Lower frequency of morning erections
  • Erectile dysfunction

Evaluation of andropause

The doctor will take a blood sample to help determine the testosterone levels as well as other hormone levels. Next, your doctor will review your symptoms and your medical history. You can also expect a physical examination by your doctor.

Testosterone replacement

Testosterone replacement therapy is often the treatment that your doctor may suggest, especially if there are certain conditions such as sexual dysfunction, type 2 diabetes or obesity (body-mass index higher than 30).

The benefits associated with testosterone replacement therapy include:

  • Improvement in sexual and erectile function
  • Improvement in bone mineral density and bone strength


The risks associated with testosterone replacement therapy include:

  • Possible decline in cardiovascular health: Although some older studies have suggested that men who received testosterone replacement therapy suffered from an increased risk of adverse cardiovascular events, current available data from interventional studies suggest that there is no increased risk with up to 3 years of testosterone therapy.
  • Acne
  • Disturbed breathing in sleep
  • Breast swelling or tenderness

Erectile Dysfunction

Erectile dysfunction, also known as ED, is a condition whereby the man struggles to get or maintain an erection during sex. While it may be normal to experience problems with erections occasionally, ED occurs routinely during sexual intercourse.

Causes of Erectile Dysfunction

ED can be caused by a number of factors, such as:

  • Vascular diseases that obstruct blood flow to the penis.

  • Neurological diseases such as stroke, which result in poor or no signal being transmitted to the penis due to damage to nerves.

  • Psychological issues such as depression and performance anxiety.

  • Trauma such as penile fractures or pelvic fractures.

  • Hormone deficiency such as andropause.

  • Drugs induced such as high blood pressure and psychiatric medications.

  • Other penile conditions such as Peyronie’s disease, phimosis or other anatomical abnormalities.

Risk factors

ED may arise from certain risk factors such as:

  • Age above 50 years old
  • Having diabetes
  • Having high blood pressure
  • Having cardiovascular diseases
  • Having high blood cholesterol
  • Smoking
  • Using drugs
  • Drinking too much alcohol
  • Obesity

Diagnostic evaluation

Your doctor will first review your medical history and do a physical examination. He or she may also order some blood tests. These blood tests may include a complete blood count, liver and kidney function tests, lipid profile, thyroid function tests and blood hormone levels.

Your doctor may also choose to conduct one or more of the following tests to help him or her with his or her diagnosis:

  • Duplex ultrasound helps to evaluate blood flow and check for signs of venous leaks, hardening of the arteries or tissue scarring.

  • Bulbocavernosus reflex helps to evaluate nerve function in the penis. During the test, the doctor squeezes the penis head, which causes the anus to contract. There is a delay in response time if there are abnormalities.

Treatment of ED

ED can be treated in 3 different ways, namely medication, shockwave therapy and surgery.

● Medication

The most common medications used to help with ED are known as phosphodiesterase-5-inhibitors (PDE5I). Examples of PDE5I are sildenafil (Viagra), vardenafil (Levitra) and tadalafil (Cialis). They can help in treating ED by increasing the blood flow to the penis, allowing you to get an erection.

However, medications might not be recommended under the following circumstances:

  • Currently on medications containing nitrates
  • Low blood pressure
  • Uncontrolled high blood pressure
  • Severe liver disease
  • Kidney disease requiring dialysis


Some side effects may include flushing, headaches and indigestion.

● Shockwave therapy

Shockwave therapy uses low-intensity and targeted sound waves to stimulate the growth of new blood vessels and improve the blood flow in the penis, which helps men to get an erection. This treatment is only suitable for vasculogenic ED.

A doctor will apply a set amount of shocks per minute for a fixed amount of time. Multiple sessions 2 to 3 weeks per week may be required. Generally, clinical improvements may take up to 3 months to be evident.

Side effects of shockwave therapy may include bruising of penile skin, blood in urine and painful erection.

● Surgery

A surgery can also be done to insert a penile implant. This is typically done when medications do not work.

A penile implant is an inflatable implant consisting of a reservoir, two cylinders and a pump that is being placed into the body. The two cylinders are placed in the penis and connected by tubing to the reservoir of fluid, which is implanted under the lower abdominal muscles. A pump is inserted under the loose skin of the scrotal sac between the testicles.

The man can inflate the prosthesis by pressing on the pump. To deflate the prosthesis, he can press the deflation valve at the base of the pump, which deflates the penis.

Premature ejaculation

Premature ejaculation is defined as consistent ejaculation within 1 minute or less of vaginal penetration in at least 75%-100% of the times of sexual intercourse over a period of at least 6 months, resulting in clinically significant distress, sexual frustration, dissatisfaction, or tension between partners.

While premature ejaculation may occur from time to time, experiencing premature ejaculation consistently may indicate an underlying issue and can negatively affect sexual relationships between couples.

Causes and risk factors

The exact cause of premature ejaculation is not known. However, some common causes of premature ejaculation may include:

  • Psychological causes such as depression, anxiety, sexual abuse, and poor body image
  • Abnormalities in hormone levels
  • Derangement of brain chemicals
  • Inflammation or infection of prostate
  • Relationship issues


Risk factors of premature ejaculation include:

  • Erectile dysfunction: Erectile dysfunction can cause premature ejaculation as the man may be worried about being unable to sustain the erection, leading to them ejaculating earlier than usual.
  • Stress: Stress can result in an inability to perform during sex, which can lead to premature ejaculation.

Treatment

Some treatments available to help with premature ejaculation are behavioural therapy and medications.

Behavioural therapy/ psychotherapy

Behavioural therapy or psychotherapy can help men with premature ejaculation by emphasising control of ejaculation by learning new techniques, encouraging better communication as well as reducing anxiety and increasing confidence.

Therapy is best used in couples where premature ejaculation is caused by performance anxiety.

Medication

Some medications that can help with premature ejaculation include:

  • Topical numbing agents: Numbing agents such as lidocaine and benzocaine can be applied on the penis 10 to 15 minutes before sexual intercourse. This can help to reduce sensation and delay ejaculation.
  • Oral medications: Oral medications can help to delay ejaculation time. Such medications include:
    • Antidepressants: Certain antidepressants such as selective short acting serotonin reuptake inhibitors (SSRIs) such as Dapoxetine can delay orgasm.
    • Pain relievers: Pain relievers such as tramadol also have side effects that can delay orgasm.
    • Phosphodiesterase-5-inhibitors: Some medications that help treat erectile dysfunction such as phosphodiesterase-5-inhibitors (PDE5I) can help increase the ejaculation latency time. Studies have also shown that PDE5I combined with SSRIs is more effective than the use of SSRIs itself.

Male Infertility

Infertility in men may occur due to a number of reasons, such as low sperm production, abnormalities in sperm functions, illnesses, injuries and even lifestyle changes. This results in lower chances of impregnating their female partners. In Singapore, 15% of Singaporean couples have difficulty getting pregnant, and 50% of these couples are due to male infertility.

Causes and risk factors

Causes of male infertility include:

  • Abnormal sperm production or function: This could be due to undescended testicles, genetic defects or health issues such as diabetes or sexually transmitted infections (e.g. chlamydia or gonorrhoea).

  • Problems with sperm delivery: This could be due to premature ejaculation, genetic medical conditions such as cystic fibrosis, structural issues such as blockage in the testicles or injury to the reproductive organ.

  • Overexposure to certain environmental factors such as pesticides and radiation. Cigarettes and alcohol can also affect fertility in men.

  • Damage due to cancer treatment: The radiation or chemotherapy used in cancer treatments can stop sperm production.

Some of the risk factors to take note of include:

  • Age: Older men are more prone to infertility compared to younger men.

  • Smoking: Smoking can increase the risk of erectile dysfunction and low sperm count in men.

  • Alcohol: Alcohol can decrease sperm count and affect sperm motility in men.

  • Being overweight: Male obesity has been linked to reduced sperm concentrations, changes in reproductive hormones, and increased sperm DNA damage.

  • Constant exposure to high-temperature environments can affect sperm count and motility.

  • Exposure to industrial or environmental toxins such as radiation can affect sperm production.

Diagnostic Tests

A spermiogram involves the sampling of semen and sending it for analysis at the laboratory. This helps evaluate male fertility.

Things that the analysis will show include:

  • pH level of sperm
  • semen volume
  • sperm concentration (number of sperms per millimetre semen)
  • sperm morphology (size and shape of sperm)
  • sperm motility (the ability of sperm to move towards an egg)
  • time to liquefaction (time taken for semen to change from a sticky substance to liquid)
  • vitality (percentage of live sperm in the sample)
  • white blood cells

Hormones assay

A hormone assay involves collecting a blood sample and sending it for analysis at the laboratory.

Hormones that are sampled include:

  • Follicle-stimulating hormones: responsible for healthy sperm production in men
  • Luteinising hormones: responsible for the stimulation of testosterone
  • Testosterone: Low levels can lead to subfertility in men
  • Prolactin: Increased levels of prolactin in men decreases the sex drive in men.

Ultrasound

An ultrasound of the scrotum can be done. This allows the doctor to detect any problems, such as an unusual mass in the scrotum, damage to tissues or structures, as well as any abnormal swelling or inflammation of the testes.

Varicocele

A varicocele is an enlargement of the veins within the loose bag of skin covering the testicles. These can cause some discomfort or pain. A varicocele may also affect the development of the testicles and result in low sperm count or infertility. If left untreated, it may lead to 3 main problems:

  • Affects fertility
  • A decrease in testosterone production
  • Scrotal discomfort


A varicocele usually does not require treatment. However, for men who are experiencing infertility due to a varicocele, surgery may be recommended as part of the fertility plan.

Varicocelectomy

A varicocelectomy involves the removal of varicoceles by cutting the veins and closing off the ends. This helps restore blood flow to the scrotum, which, in turn, increases sperm and testosterone production.

A semen analysis can be done post-surgery to discern whether fertility improves.

Other anatomical penile abnormalities

Penile Curvature (Peyronie’s Disease)

Penile curvature, also known as Peyronie’s disease, is a condition whereby scar tissues form under the skin of the penis. The scar tissues pull on the surrounding tissues and cause the penis to curve or bend. This can make erections painful, which can affect sexual intercourse.

Penile curvature can occur due to:

  • injury to penis
  • autoimmune disorder
  • a person having both diabetes and erectile dysfunction
  • a person having history of prostate cancer treatment with surgery

Penile curvature surgery

Penile curvature refers to the condition where the penis is curved during an erection. Penile curvature surgery helps to correct this curvature. However, it is usually only recommended for severe patients who do not respond to non-surgical treatments.

There are several techniques used in penile curvature surgery, namely:

  • Plication: This technique inserts stitches at the longer side of the penis to pull the penis to the middle. This surgery poses the least risk of impotence and will take about 1 hour to complete the surgery.

  • Grafting: This technique involves making an incision on the shorter side of the penis, and a graft (a vein or a small intestine graft from a pig) is inserted to match the longer side of penis. This surgery can increase the penile length by about half to one inch.

  • Penile prosthesis: A prosthesis is placed to help straighten the penis. This surgery takes about 3-4 hours.

Varicocelectomy

A varicocelectomy involves the removal of varicoceles by cutting the veins and closing off the ends. This helps restore blood flow to the scrotum, which, in turn, increases sperm and testosterone production.

A semen analysis can be done post-surgery to discern whether fertility improves.

Summary

All in all, many andrological issues can be treated or managed. The most important thing is to seek professional help as soon as possible if you feel like you may be suffering from an andrological condition.

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